Electrochemical detection of dopamine and cytochrome c at a nanostructured gold electrode

Plowman, B, Mahajan, M, O'Mullane, A and Bhargava, S 2010, 'Electrochemical detection of dopamine and cytochrome c at a nanostructured gold electrode', Electrochimica Acta, vol. 55, no. 28, pp. 8953-8959.


Document type: Journal Article
Collection: Journal Articles

Title Electrochemical detection of dopamine and cytochrome c at a nanostructured gold electrode
Author(s) Plowman, B
Mahajan, M
O'Mullane, A
Bhargava, S
Year 2010
Journal name Electrochimica Acta
Volume number 55
Issue number 28
Start page 8953
End page 8959
Total pages 7
Publisher Pergamon-Elsevier Science Ltd
Abstract A nanostructured gold surface consisting of closely packed outwardly growing spikes is investigated for the electrochemical detection of dopamine and cytochrome c. A significant electrocatalytic effect for the electrooxidation of both dopamine and ascorbic acid at the nanostructured electrode was found due to the presence of surface active sites which allowed the detection of dopamine in the presence of excess ascorbic acid to be achieved by differential pulse voltammetry. By simple modification with a layer of Nafion, the enhanced electrocatalytic properties of the nanostructured surface was maintained while increasing the selectivity of dopamine detection in the presence of interfering species such as excess ascorbic and uric acids. Also, upon modification of the nanostructured surface with a monolayer of cysteine, the electrochemical response of immobilised cytochrome c in two distinct conformations was observed. This opens up the possibility of using such a nanostructured surface for the characterisation of other biomolecules and in bio-electroanalytical applications.
Subject Electrochemistry
Keyword(s) Self-Assembled Monolayers
Glassy-Carbon Electrode
Aqueous Acid-Solution
Ascorbic-Acid
Electrocatalytic Oxidation
Au Nanoparticles
Paste Electrode
Surface-States
Uric-Acid
Behavior
Nanostructured gold
Dopamine
Cytochrome c
Voltammetry
DOI - identifier 10.1016/j.electacta.2010.08.045
Copyright notice © 2010 Elsevier Ltd. All rights reserved.
ISSN 0013-4686
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