Gold nanoparticles: novel radiobiological dose enhancement studies for radiation therapy, synchrotron based microbeam and stereotactic radiotherapy

W Abd Rahman, W 2010, Gold nanoparticles: novel radiobiological dose enhancement studies for radiation therapy, synchrotron based microbeam and stereotactic radiotherapy, Doctor of Philosophy (PhD), Medical Sciences, RMIT University.


Document type: Thesis
Collection: Theses

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Title Gold nanoparticles: novel radiobiological dose enhancement studies for radiation therapy, synchrotron based microbeam and stereotactic radiotherapy
Author(s) W Abd Rahman, W
Year 2010
Abstract High atomic number (Z) materials such as iodine and gadolinium have been successfully used as dose enhancers in preclinical radiotherapy. A competing high Z dose enhancement is achieved by the application of gold nanoparticles (AuNPs), which provides the advantages of tumour specificity and vascular permeability. The main aim of this thesis was to investigate the application of AuNPs as dose enhancers for various radiotherapy techniques; specifically focusing on superficial radiotherapy (SXRT), microbeam radiotherapy (MRT) and synchrotron based stereotactic radiosurgery (SSR). The effects of AuNPs on radiation dose enhancement have been comprehensively analysed using biological and phantom studies. Results show that AuNPs enhance radiation dose especially in the SXRT energy range and have potential to be applied for MRT and SSR. Radiobiological analysis also found changes in the linear quadratic parameters indicating increases in DNA damage for cells treated with AuNPs in combination with radiation. Observation of the influence of AuNPs on normal and cancerous cell migration found the increase in the acceleration of the cell migration which is known to indicate improved normal tissue recovery. Phantom studies conducted using polymer gels impregnated with AuNPs found the results were in agreement with the biological studies. Inclusion of metallic nanoparticles in polymer gels represents first precedent in this field and the results show that AuNPs can be impregnated in a radiosensitive polymer gel and can be applied as a dosimeter in medical radiation. In the prevailing clinical circumstance where radiotherapy dose is constrained by normal tissue tolerance, AuNPs can potentially be applied as a novel radiobiological dose enhancers and this enhancement could in the future be used to improve therapeutic efficacy of radiotherapy.
Degree Doctor of Philosophy (PhD)
Institution RMIT University
School, Department or Centre Medical Sciences
Keyword(s) Gold Nanoparticles
Radiotherapy
Polymer Gel Dosimeter
Synchrotron Radiation
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