Computer simulation studies of abnormal protein aggregation

Computer simulation studies of abnormal protein aggregation

Hung, A, Todorova, N and Yarovsky, I 2009, 'Computer simulation studies of abnormal protein aggregation', in C.A. Long, P. Anninos, T. Pham, G. Anastassopoulos, N.E. Mastorakis (ed.) Proceedings of the 2nd WSEAS International Conference on Biomedical Electronics and Biomedical Informatics: BEBI 09, Moscow, Russia, 20-22 August 2009, pp. 41-46.

Document type:	Conference Paper
Collection:	Conference Papers

Title	Computer simulation studies of abnormal protein aggregation
Author(s)	Hung, A Todorova, N Yarovsky, I
Year	2009
Conference name	WSEAS International Conference on Biomedical Electronics and Biomedical Informatics
Conference location	Moscow, Russia
Conference dates	20-22 August 2009
Proceedings title	Proceedings of the 2nd WSEAS International Conference on Biomedical Electronics and Biomedical Informatics: BEBI 09
Editor(s)	C.A. Long, P. Anninos, T. Pham, G. Anastassopoulos, N.E. Mastorakis
Publisher	WSEAS Press
Place of publication	Moscow, Russia
Start page	41
End page	46
Total pages	6
Abstract	This paper describes computer modelling studies using classical Molecular Dynamics techniques and their derivative methods such as umbrella sampling and coarse grain simulations to study protein behaviour in various environments causing their partial unfolding and aggregation. We present an overview of a series of theoretical studies which provided fundamental insights into the molecular mechanisms of self assembly of apolipoprotein C-II (ApoC-II) which is involved in blood lipid transport and shows a tendency to misfold and aggregate into insoluble amyloid fibrils.
Subjects	Condensed Matter Physics not elsewhere classified Physical Chemistry not elsewhere classified
Keyword(s)	protein misfolding protein aggregation molecular dynamics simulations amyloid fibrils
Copyright notice	© 2009 WSEAS Press
ISBN	9789604741106

Citation counts:	Cited 0 times in TR Web of Science Cited 0 times in Scopus Article
Access Statistics:	34 Abstract Views - Detailed Statistics
Created:	Fri, 04 Nov 2011, 08:38:00 EST by Catalyst Administrator