Peptide-mediated delivery of gold nanoparticles and proteins into lysosomes of mammalian cells

Dekiwadia, C 2010, Peptide-mediated delivery of gold nanoparticles and proteins into lysosomes of mammalian cells, Doctor of Philosophy (PhD), Applied Sciences, RMIT University.


Document type: Thesis
Collection: Theses

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Title Peptide-mediated delivery of gold nanoparticles and proteins into lysosomes of mammalian cells
Author(s) Dekiwadia, C
Year 2010
Abstract Dr Chaitali Dekiwadia has developed a therapeutic approach of targeting gold nanoparticles and proteins to the lysosomes mediated through peptides. She designed and synthesised peptides to deliver a protein-nanoparticle conjugates to the lysosomes penetrating the challenging cell membrane barrier. This novel work has shown for the first time that protein-nanoparticle conjugates could be targeted to lysosomes using short peptides. This peptide-mediated approach could underpin the development of a novel strategy thereby widening the pharmaceutical index for current lysosomal storage diseases.
Degree Doctor of Philosophy (PhD)
Institution RMIT University
School, Department or Centre Applied Sciences
Keyword(s) Peptides
gold nanoparticles
lysosomes
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Created: Thu, 10 Nov 2011, 14:47:16 EST by Guy Aron
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