A study of fluorinated ß-Nitrostyrenes as antimicrobial

Lo, K, Cornell, H, Nicoletti, A, Jackson, N and Hugel, H 2012, 'A study of fluorinated ß-Nitrostyrenes as antimicrobial', Applied Sciences, vol. 2, no. 1, pp. 114-128.

Document type: Journal Article
Collection: Journal Articles

Title A study of fluorinated ß-Nitrostyrenes as antimicrobial
Author(s) Lo, K
Cornell, H
Nicoletti, A
Jackson, N
Hugel, H
Year 2012
Journal name Applied Sciences
Volume number 2
Issue number 1
Start page 114
End page 128
Total pages 15
Publisher M D P I AG
Abstract The effect of variously fluorine-substituted ß-methyl-ß-nitrostyrenes on their antimicrobial activity was investigated. Their efficacy was determined by minimum inhibition concentration (MIC) in cultures of Gram positive and Gram negative bacteria and a fungus. Highest activity against the Gram negative bacterium, E.coli, was achieved with 4-fluorine-aryl substituted ß-methyl-ß-nitrostyrenes, while most compounds gave excellent results against gram positive bacteria. Importantly, the addition of the ß-methyl group profoundly enhanced the antibacterial activity of the compounds tested. The comparative KD values for the most potent compounds against E.coli were much lower than those required for the gram positive and fungus counterparts. This investigation illustrated that fluorine substituted nitropropenylarenes have enhanced antimicrobial activity suitable for antibiotic applications.
Subject Natural Products Chemistry
Keyword(s) antimicrobial agents
Henry reaction
partition coefficients
log P values
DOI - identifier 10.3390/app2010114
Copyright notice © 2012 Authors
ISSN 2076-3417
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