Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model

Wong, K, Thavornpattanapong, P, Cheung, S, Sun, Z and Tu, J 2012, 'Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model', BMC Cardiovascular Disorders, vol. 12, pp. 1-18.


Document type: Journal Article
Collection: Journal Articles

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Title Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model
Author(s) Wong, K
Thavornpattanapong, P
Cheung, S
Sun, Z
Tu, J
Year 2012
Journal name BMC Cardiovascular Disorders
Volume number 12
Start page 1
End page 18
Total pages 18
Publisher BioMed Central Ltd.
Abstract Background: This study characterizes the distribution and components of plaque structure by presenting a three-dimensional blood-vessel modelling with the aim of determining mechanical properties due to the effect of lipid core and calcification within a plaque. Numerical simulation has been used to answer how cap thickness and calcium distribution in lipids influence the biomechanical stress on the plaque.Method: Modelling atherosclerotic plaque based on structural analysis confirms the rationale for plaque mechanical examination and the feasibility of our simulation model. Meaningful validation of predictions from modelled atherosclerotic plaque model typically requires examination of bona fide atherosclerotic lesions. To analyze a more accurate plaque rupture, fluid-structure interaction is applied to three-dimensional blood-vessel carotid bifurcation modelling.
Subject Computational Fluid Dynamics
Keyword(s) Atherosclerosis
Calcification
Fibrous cap
Lipids
Plaque rupture
DOI - identifier 10.1186/1471-2261-12-7
Copyright notice © 2012 Wong et al; licensee BioMed Central Ltd
ISSN 14712261
Additional Notes Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
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Created: Fri, 25 May 2012, 12:57:00 EST by Catalyst Administrator
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