Optimizing protein delivery to promote skeletal muscle protein synthesis

Areta, J 2013, Optimizing protein delivery to promote skeletal muscle protein synthesis, Doctor of Philosophy (PhD), Medical Sciences, RMIT University.

Document type: Thesis
Collection: Theses

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Title Optimizing protein delivery to promote skeletal muscle protein synthesis
Author(s) Areta, J
Year 2013
Abstract Resistance exercise and protein ingestion are synergistic in their capacity to stimulate muscle protein synthesis. Previous research has examined the effect of various factors related to protein ingestion (e.g. amount, type, co-ingestion with carbohydrates and proximity to resistance exercise) and their capacity to modulate muscle protein synthesis. However, there are many deficiencies in our current knowledge regarding the effect of several modifiable factors related to amino acid provision that may alter muscle protein synthesis. Therefore, the aim of this thesis was to determine 1) the anabolic effect of leucine on skeletal muscle cells, 2) the capacity for differences in the timing and distribution of protein ingestion to modulate skeletal muscle protein synthesis after a bout of resistance exercise, and 3) the effect of resistance exercise and protein ingestion on the skeletal muscle anabolic response during dietary-induced energy deficit.
Degree Doctor of Philosophy (PhD)
Institution RMIT University
School, Department or Centre Medical Sciences
Keyword(s) skeletal muscle
myofibrillar protein synthesis
protein ingestion
fractional synthetic rate
energy deficit
energy availability
weight loss
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Created: Tue, 25 Mar 2014, 11:38:55 EST by Keely Chapman
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