Atomistic insights into the effects of electromagnetic fields on an amyloidogenic peptide

Bentvelzen, A 2018, Atomistic insights into the effects of electromagnetic fields on an amyloidogenic peptide, Masters by Research, Engineering, RMIT University.


Document type: Thesis
Collection: Theses

Attached Files
Name Description MIMEType Size
Bentvelzen.pdf Thesis application/pdf 3.18MB
Title Atomistic insights into the effects of electromagnetic fields on an amyloidogenic peptide
Author(s) Bentvelzen, A
Year 2018
Abstract In this thesis computational modelling was used to investigate on the atomistic scale, the effects of external electric and electromagnetic fields (EMF) on protein behaviour and responses in an aqueous environment. The motivation behind this study is discussed in Chapter 1, along with a literature review on previous research on the effects of EMF on proteins, from both simulation based studies and experimental research.

Non-Equilibrium Molecular Dynamics was employed to simulate the protein response to external perturbations and the computational methodologies encompassing this technique are described in Chapter 2. The history of NEMD is also described in this chapter, along with the specific computational details for the simulation of our peptide model, apoC-II(60-70) exposed to EMFs of static/oscillating nature and different frequency and strength.

In Chapter we used all-atom NEMD simulations to understand and quantify the response mechanisms of the amyloidogenic apoC-II (60-70) peptides to non-ionising radiation by modelling their behaviour under static electromagnetic and electric fields ofdifferent strengths.

Chapter 4 expands on the previous study by investigating the role of the field frequency on the peptide behaviour in solution. Finally, Chapter 5 presents a summary of the conclusions drawn from this work.
Degree Masters by Research
Institution RMIT University
School, Department or Centre Engineering
Subjects Materials Engineering not elsewhere classified
Keyword(s) Electromagnetic fields
Amyloidogenic proteins
Apolipoprotein C-II
Electric fields
Molecular dynamics
Versions
Version Filter Type
Access Statistics: 41 Abstract Views, 56 File Downloads  -  Detailed Statistics
Created: Tue, 27 Nov 2018, 09:53:46 EST by Keely Chapman
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us