Paediatric food allergy and the role of vitamin D

Zakariaee Abkoo, R 2019, Paediatric food allergy and the role of vitamin D, Doctor of Philosophy (PhD), Health and Biomedical Sciences, RMIT University.

Document type: Thesis
Collection: Theses

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Title Paediatric food allergy and the role of vitamin D
Author(s) Zakariaee Abkoo, R
Year 2019
Abstract Vitamin D plays a significant role in multiple physiological functions in humans. The prevalence of paediatric food allergy (FA) has been tentatively linked to vitamin D insufficiency. In Victoria, Australia, the frequency of both vitamin D insufficiency and paediatric FA is high.Vitamin D conventionally is measured in serum / plasma and the interpretation cut-offs for adults are well-defined. However, the interest in the use of dried blood spots (DBS) as an alternative matrix for vitamin D assessment has increased or large-scale population studies. we aimed to develop a sensitive and robust local DBS vitamin D method, to to provide a description of vitamin D levels at birth in the Melbournian infant population and investigate the association between vitamin D status and prevalence of paediatric FA and eczema in early childhood. We developed a sensitive liquid chromatography tandem mass spectrometery method and measured vitamin D from 2700 newborns' DBS samples. Our research demonstrated that, vitamin D levels in newborn babies is influenced by season of birth and maternal vitamin D supplementation. Lower vitamin D levels do not influence the risk of challenge-proven FA or eczema in infancy. Further studies are required to define age appropriate decision limits for vitamin D.
Degree Doctor of Philosophy (PhD)
Institution RMIT University
School, Department or Centre Health and Biomedical Sciences
Subjects Paediatrics
Keyword(s) Vitamin D
Paediatric food allergy
Dried blood spot
Liquid chromatography tandem mass spectrometery
Vitamin D deficiency
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Created: Thu, 29 Aug 2019, 11:15:28 EST by Adam Rivett
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