Determination of pulmonary gases (O2 and CO2) metabolic-rates and lung diffusion coefficients based on the inspired and expired air compositions and venous blood and gas concentration

Loh, K, Ghista, D and Rudolph, H 2005, 'Determination of pulmonary gases (O2 and CO2) metabolic-rates and lung diffusion coefficients based on the inspired and expired air compositions and venous blood and gas concentration', in C. Roux and T. G. Zhuang (ed.) Proceedings of the 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Shanghai, 17-18 January 2006.


Document type: Conference Paper
Collection: Conference Papers

Title Determination of pulmonary gases (O2 and CO2) metabolic-rates and lung diffusion coefficients based on the inspired and expired air compositions and venous blood and gas concentration
Author(s) Loh, K
Ghista, D
Rudolph, H
Year 2005
Conference name International Conference of the Engineering in Medicine and Biology Society
Conference location Shanghai
Conference dates 17-18 January 2006
Proceedings title Proceedings of the 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Editor(s) C. Roux
T. G. Zhuang
Publisher IEEE
Place of publication Shanghai
Abstract The primary function of the lung is to (i) oxygenate the blood and thereby provide oxygen to the cells for metabolization purposes, and (ii) to remove the CO2 produced by the tissues from the pulmonary blood. Herein, we provide a noninvasive methodology to asses the capacity of the lung to oxygenate the pulmonary capillary blood and to reduce its CO2 concentration. For this purpose, we analyze the compositions of the inspired and expired air per breath, and therefrom compute the metabolic O2 consumption rate (V(O2)) and CO2 production rate (V(CO2)). Next we compute the cardiac out (CO) as CO = V(O 2) (C(O2)AB - C(O2)VB ). We have derived the expressions for diffusion coefficients (i) D(O2) in terms of V(O2) and the alveolar and venous partial pressures, P(O2)al and P(O2 )VB and (ii) DC(O2) in terms of VC(O2 ), P(CO2)al and PC(O2)VB . The coefficients D(O2) and D(CO2) represent the gas transfer capacity of the lung. The paper provides a case study for the determination of Q, D(O2) and DC(OO2 ). The derived information of DO2 and DC(O2) as well as of (O2) and C(O2) metabolic rates can be of considerable clinical use including for SARS assessment
Subjects Biomedical Engineering not elsewhere classified
Keyword(s) gas exchange
O2 metabolic-rates
CO2 metabolic-rates
diffusion coefficients DO2
diffusion coefficients DCO2
blood flow rate
DOI - identifier 10.1109/IEMBS.2005.1615901
Copyright notice © 2005 IEEE
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