Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds

Zeng, X, Zhou, X, Xu, J, Chan, S, Xue, C, Molero - Navajas, J and Ye, J 2012, 'Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds', Biochemical Pharmacology, vol. 84, no. 6, pp. 830-837.


Document type: Journal Article
Collection: Journal Articles

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Title Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds
Author(s) Zeng, X
Zhou, X
Xu, J
Chan, S
Xue, C
Molero - Navajas, J
Ye, J
Year 2012
Journal name Biochemical Pharmacology
Volume number 84
Issue number 6
Start page 830
End page 837
Total pages 8
Publisher Elsevier
Abstract Reducing lipid accumulation in insulin target tissues is critical for the treatment of type 2 diabetes. This study aimed to develop a biochemical assay in cells for high throughput (HTP) screening of anti-diabetic drugs by reducing lipid accumulation via different mechanisms.
Subject Pharmacology and Pharmaceutical Sciences not elsewhere classified
Keyword(s) Drug discovery
Phenotypic screening
Lipid accumulation
Insulin resistance
Obesity
Fatty liver
DOI - identifier 10.1016/j.bcp.2012.07.003
Copyright notice © 2012 Elsevier Inc. All rights reserved.
ISSN 0006-2952
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