The expression of the low-affinity neurotrophin receptor, p75NTR, is upregulated by oligodendroglial progenitors adjacent to the subventricular zone in response to demyelination

Petratos, S, Gonzales, M, Azari, M, Marriott, M, Profyris, C, Minichello, R, Nicolaou, A, Shipham, K, Boyle, K, Cheema, S and Kilpatrick, T 2004, 'The expression of the low-affinity neurotrophin receptor, p75NTR, is upregulated by oligodendroglial progenitors adjacent to the subventricular zone in response to demyelination', GLIA, vol. 48, no. 1, pp. 64-75.


Document type: Journal Article
Collection: Journal Articles

Title The expression of the low-affinity neurotrophin receptor, p75NTR, is upregulated by oligodendroglial progenitors adjacent to the subventricular zone in response to demyelination
Author(s) Petratos, S
Gonzales, M
Azari, M
Marriott, M
Profyris, C
Minichello, R
Nicolaou, A
Shipham, K
Boyle, K
Cheema, S
Kilpatrick, T
Year 2004
Journal name GLIA
Volume number 48
Issue number 1
Start page 64
End page 75
Total pages 12
Publisher John Wiley & Sons, Inc.
Abstract Precursor cells have the capacity to repopulate the demyelinated brain, but the molecular mechanisms that facilitate their recruitment are largely unknown. The lowaffinity neurotrophin receptor, p75NTR, may be one of these regulators; however, its expression profile by oligodendroglia within the multiple sclerosis (MS) brain remains uncertain. We therefore assessed the expression profile of this receptor within 8 MS and 4 control brains. We found no evidence of expression of p75NTR by mature oligodendrocytes
Subject Central Nervous System
Keyword(s) oligodendroglial progenitor cells
multiple sclerosis
chronic demyelination
low-affinity neurotrophin receptor
chondroitin sulfate proteoglycan NG2
apoptosis
DOI - identifier 10.1002/glia.20056
Copyright notice © 2004 Wiley-Liss, Inc
ISSN 0894-1491
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