Induction of endogenous neural precursors in mouse models of spinal cord injury and disease

Azari, M, Zang, D, Profyris, C, Petratos, S and Cheema, S 2005, 'Induction of endogenous neural precursors in mouse models of spinal cord injury and disease', European Journal of Neurology, vol. 12, no. 8, pp. 638-648.


Document type: Journal Article
Collection: Journal Articles

Title Induction of endogenous neural precursors in mouse models of spinal cord injury and disease
Author(s) Azari, M
Zang, D
Profyris, C
Petratos, S
Cheema, S
Year 2005
Journal name European Journal of Neurology
Volume number 12
Issue number 8
Start page 638
End page 648
Total pages 11
Publisher Wiley-Blackwell Publishing Ltd.
Abstract Adult neural precursor cells (NPCs) in the mammalian central nervous system (CNS) have been demonstrated to be responsive to conditions of injury and disease. Here we investigated the response of NPCs in mouse models of spinal cord disease [motor neuron disease (MND)] with and without sciatic nerve axotomy, and spinal cord injury (SCI). We found that neither axotomy, nor MND alone brought about a response by Nestin-positive NPCs. However, the combination of the two resulted in mobilization of NPCs in the spinal cord
Subject Neurology and Neuromuscular Diseases
Keyword(s) leukaemia inhibitory factor
motor neuron disease
neural precursor
sciatic axotomy
spinal cord injury
DOI - identifier 10.1111/j.1468-1331.2005.01066.x
Copyright notice © 2005 EFNS
ISSN 1351-5101
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