Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS

Azari, M, Profyris, C, Lopes, E, Le Grande, M, Petratos, S and Cheema, S 2005, 'Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS', European Journal of Neurology, vol. 12, no. 5, pp. 357-364.

Document type: Journal Article
Collection: Journal Articles

Title Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS
Author(s) Azari, M
Profyris, C
Lopes, E
Le Grande, M
Petratos, S
Cheema, S
Year 2005
Journal name European Journal of Neurology
Volume number 12
Issue number 5
Start page 357
End page 364
Total pages 8
Publisher Wiley-Blackwell Publishing Ltd.
Abstract There is increasing evidence that inflammatory mechanisms are involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). Inhibition of a key mediator of inflammation, cyclooxygenase 2 (COX-2), represents a promising therapeutic approach in ALS. Here we tested the in vivo effects of a specific COX-2 inhibitor, Rofecoxib, administered by intraperitoneal injection, in the SOD1 G93A G1H mouse model of the familial form of ALS (fALS). Rofecoxib administration commenced at postnatal day 60 (P60), since the hallmarks of in?ammation in the spinal cord were found to occur beyond this time-point in this mouse model of fALS. We found a significant but small delay in the onset of locomotor impairment in mice treated with Rofecoxib at the dose of 10 mg/kg of weight. However, survival was not effected by treatment. As prostaglandin E2 levels in spinal cord or in plasma were not reduced by Rofecoxib treatment, these results may suggest lack of sufficient bioavailability as the reason for the modest clinical changes observed
Subject Clinical Sciences not elsewhere classified
Keyword(s) amyotrophic lateral sclerosis
cyclooxygenase 2
prostaglandin E2
soluble tumour necrosis factor receptor
DOI - identifier 10.1111/j.1468-1331.2004.00987.x
Copyright notice © 2005 EFNS European Journal of Neurology
ISSN 1351-5101
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Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
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