Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation

Petratos, S, Ozturk, E, Azari, M, Kenny, R, Young Lee, J, Magee, K, Harvey, A, McDonald, C, Taghian, K, Moussa, L, Mun Aui, P, Siatskas, C, Litwak, S, Fehlings, M, Strittmatter, S and Bernard, C 2012, 'Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation', Brain, vol. 135, no. 6, pp. 1794-1818.


Document type: Journal Article
Collection: Journal Articles

Title Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation
Author(s) Petratos, S
Ozturk, E
Azari, M
Kenny, R
Young Lee, J
Magee, K
Harvey, A
McDonald, C
Taghian, K
Moussa, L
Mun Aui, P
Siatskas, C
Litwak, S
Fehlings, M
Strittmatter, S
Bernard, C
Year 2012
Journal name Brain
Volume number 135
Issue number 6
Start page 1794
End page 1818
Total pages 25
Publisher Oxford University Press
Abstract Multiple sclerosis involves demyelination and axonal degeneration of the central nervous system. The molecular mechanisms of axonal degeneration are relatively unexplored in both multiple sclerosis and its mouse model, experimental autoimmune encephalomyelitis. We previously reported that targeting the axonal growth inhibitor, Nogo-A, may protect against neurodegeneration in experimental autoimmune encephalomyelitis; however, the mechanism by which this occurs is unclear. We now show that the collapsin response mediator protein 2 (CRMP-2), an important tubulin-associated protein that regulates axonal growth, is phosphorylated and hence inhibited during the progression of experimental autoimmune encephalomyelitis in degenerating axons.
Subject Cellular Nervous System
Keyword(s) axonal degeneration
collapsin response mediator protein 2
experimental autoimmune encephalomyelitis
Nogo receptor
Nogo-A
DOI - identifier 10.1093/brain/aws100
Copyright notice © The Author (2012)
ISSN 0006-8950
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