Mesenchymal stem cells for treatment of CNS injury

Azari, M, Mathias, L, Ozturk, E, Cram, D, Boyd, R and Petratos, S 2010, 'Mesenchymal stem cells for treatment of CNS injury', Current Neuropharmacology, vol. 8, no. 4, pp. 316-323.


Document type: Journal Article
Collection: Journal Articles

Title Mesenchymal stem cells for treatment of CNS injury
Author(s) Azari, M
Mathias, L
Ozturk, E
Cram, D
Boyd, R
Petratos, S
Year 2010
Journal name Current Neuropharmacology
Volume number 8
Issue number 4
Start page 316
End page 323
Total pages 8
Publisher Bentham Science Publishers
Abstract Brain and spinal cord injuries present significant therapeutic challenges. The treatments available for these conditions are largely ineffective, partly due to limitations in directly targeting the therapeutic agents to sites of pathology within the central nervous system (CNS). The use of stem cells to treat these conditions presents a novel therapeutic strategy. A variety of stem cell treatments have been examined in animal models of CNS trauma. Many of these studies have used stem cells as a cell-replacement strategy. These investigations have also highlighted the significant limitations of this approach. Another potential strategy for stem cell therapy utilises stem cells as a delivery mechanism for therapeutic molecules. This review surveys the literature relevant to the potential of mesenchymal stem cells for delivery of therapeutic agents in CNS trauma in humans.
Subject Cellular Nervous System
Keyword(s) Spinal-Cord-Injury
Traumatic Brain-Injury
Marrow Stromal Cells
Promote Axonal Regeneration
Bdnf-Producing Fibroblasts
Messenger-Rna Expression
Artery Occlusion Model
Adult-Mouse Brain
Bone-Marrow
Functional Recovery
DOI - identifier 10.2174/157015910793358204
Copyright notice © 2010 Bentham Science Publishers Ltd
ISSN 1570-159X
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