Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A) (G1H) mouse model of familial amyotrophic lateral sclerosis

Azari, M, Lopes, E, Stubna, C, Turner, B, Zang, D, Nicola, N, Kurek, J and Cheema, S 2003, 'Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A) (G1H) mouse model of familial amyotrophic lateral sclerosis', Brain Research, vol. 982, no. 1, pp. 92-97.


Document type: Journal Article
Collection: Journal Articles

Title Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A) (G1H) mouse model of familial amyotrophic lateral sclerosis
Author(s) Azari, M
Lopes, E
Stubna, C
Turner, B
Zang, D
Nicola, N
Kurek, J
Cheema, S
Year 2003
Journal name Brain Research
Volume number 982
Issue number 1
Start page 92
End page 97
Total pages 6
Publisher Elsevier BV
Abstract We investigated the anatomical and behavioural effects of daily intraperitoneal injection of 25 mg/kg of LIF in the SOD1 mouse model of familial ALS. We found some subtle beneficial behavioural changes in LIF treated mice. These included later onset of clinical disease in females as determined by clinical scoring; better grip strength in males; and delayed development of motor impairment in males as determined by the rotarod test. However, we found no significant rescue of motoneurons or prolongation of survival as a result PASS of this systemic dose of LIF in these mice
Subject Cellular Nervous System
Keyword(s) Disorders of the nervous system
Degenerative disease: Other
Leukemia inhibitory factor
SOD1 G93A transgenic mice
Spinal motoneuron
Neuroprotective
DOI - identifier 10.1016/S0006-8993(03)02989-5
Copyright notice © 2003 Elsevier B.V
ISSN 0006-8993
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