Investigation of the biological properties of cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis

Rafehi, H, Ververis, K, Balcerczyk, A, Ziemann, M, Ooi, J, Hu, S, Kwa, F, Loveridge, S, Georgiadis, G, El-Osta, A and Karagiannis, T 2012, 'Investigation of the biological properties of cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis', Pathobiology of Aging & Age Related Diseases, vol. 2, pp. 1-14.


Document type: Journal Article
Collection: Journal Articles

Title Investigation of the biological properties of cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis
Author(s) Rafehi, H
Ververis, K
Balcerczyk, A
Ziemann, M
Ooi, J
Hu, S
Kwa, F
Loveridge, S
Georgiadis, G
El-Osta, A
Karagiannis, T
Year 2012
Journal name Pathobiology of Aging & Age Related Diseases
Volume number 2
Start page 1
End page 14
Total pages 14
Publisher Co-Action Publishing
Abstract The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF†, represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.
Subject Molecular Medicine
Keyword(s) cinnulin PF
diabetes
diabetic complications
diabetic ulcer
mRNA-Seq
DOI - identifier 10.3402/pba.v2i0.11905
Copyright notice © 2012 Haloom Rafehi et al.
ISSN 2001-0001
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