Oral huangqi formulae for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis

Wu, L, Chen, Y, Xu, Y, Guo, X, Li, X, Zhang, A, May, B, Xue, C, Wen, Z and Lin, L 2013, 'Oral huangqi formulae for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis', Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1-14.


Document type: Journal Article
Collection: Journal Articles

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Title Oral huangqi formulae for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
Author(s) Wu, L
Chen, Y
Xu, Y
Guo, X
Li, X
Zhang, A
May, B
Xue, C
Wen, Z
Lin, L
Year 2013
Journal name Evidence-Based Complementary and Alternative Medicine
Volume number 2013
Start page 1
End page 14
Total pages 14
Publisher Hindawi Publishing Corporation
Abstract Objective. To evaluate the efficacy and safety of oral Huangqi formulae for the treatment of stable COPD. Methods. The major databases were searched until September 2010 and supplemented with a manual search. Randomized controlled trials (RCTs) of oral Huangqi formulae that reported on lung function, St. George’s Respiratory Questionnaire, symptom improvement and/or frequency of exacerbations were extracted by two reviewers.The Cochrane tool was used for the assessment of risk of bias in the included trials. Data were analyzed with RevMan 5.1.2 software. Results. 25 RCTs (1,661 participants) were included. Compared with conventional therapy (CT) alone, oral Huangqi formulae plus CT increased FEV1, and a similar result was found comparing Huangqi formulae with no treatment. Improvements in SGRQ total score, COPD-related symptoms and reduction of frequency of exacerbations were found in patients receiving Huangqi formulae plus CT compared to those receiving CT alone or CT plus placebo. No serious adverse events were reported. However, there were some methodological inadequacies in the included studies. Conclusions.The benefits of Huangqi formulae for stable COPDwere promising, but its efficacy and safety have not been established due to methodological weakness and possible bias in the reported results. Further rigorously designed studies are warranted.
Subject Traditional Chinese Medicine and Treatments
DOI - identifier 10.1155/2013/705315
Copyright notice © 2013 Lei Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ISSN 1741-427X
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