Expression of flavonoid 3',5'-hydroxylase and acetolactate synthase genes in transgenic carnation: Assessing the safety of a nonfood plant

Chandler, S, Senior, M, Nakamura, N, Tsuda, S and Tanaka, Y 2013, 'Expression of flavonoid 3',5'-hydroxylase and acetolactate synthase genes in transgenic carnation: Assessing the safety of a nonfood plant', Journal of Agricultural and Food Chemistry, vol. 61, no. 48, pp. 11711-11720.


Document type: Journal Article
Collection: Journal Articles

Title Expression of flavonoid 3',5'-hydroxylase and acetolactate synthase genes in transgenic carnation: Assessing the safety of a nonfood plant
Author(s) Chandler, S
Senior, M
Nakamura, N
Tsuda, S
Tanaka, Y
Year 2013
Journal name Journal of Agricultural and Food Chemistry
Volume number 61
Issue number 48
Start page 11711
End page 11720
Total pages 10
Publisher American Chemical Society
Abstract For 16 years, genetically modified flowers of carnation (Dianthus caryophyllus) have been sold to the floristry industry. The transgenic carnation carries a herbicide tolerance gene (a mutant gene encoding acetolactate synthase (ALS)) and has been modified to produce delphinidin-based anthocyanins in flowers, which conventionally bred carnation cannot produce. The modified flower color has been achieved by introduction of a gene encoding flavonoid 3′,5′-hydroxylase (F3′5′H). Transgenic carnation flowers are produced in South America and are primarily distributed to North America, Europe, and Japan. Although a nonfood crop, the release of the genetically modified carnation varieties required an environmental risk impact assessment and an assessment of the potential for any increased risk of harm to human or animal health compared to conventionally bred carnation. The results of the health safety assessment and the experimental studies that accompanied them are described in this review. The conclusion from the assessments has been that the release of genetically modified carnation varieties which express F3′5′H and ALS genes and which accumulate delphinidin-based anthocyanins do not pose an increased risk of harm to human or animal health.
Subject Genetically Modified Horticulture Plants
Keyword(s) Carnation
delphinidin
flavonoid 3
′5′-hydroxylase
risk assessment
acetolactate synthase
DOI - identifier 10.1021/jf4004384
Copyright notice © 2013 American Chemical Society
ISSN 0021-8561
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