FOLFOX 4 combined with herbal medicine for advanced colorectal cancer: A systematic review

Chen, M, May, B, Zhou, W, Xue, C and Zhang, A 2013, 'FOLFOX 4 combined with herbal medicine for advanced colorectal cancer: A systematic review', Phytotherapy Research, pp. 1-16.


Document type: Journal Article
Collection: Journal Articles

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Title FOLFOX 4 combined with herbal medicine for advanced colorectal cancer: A systematic review
Author(s) Chen, M
May, B
Zhou, W
Xue, C
Zhang, A
Year 2013
Journal name Phytotherapy Research
Start page 1
End page 16
Total pages 16
Publisher John Wiley & Sons
Abstract This systematic review evaluates the clinical evidence for the addition of herbal medicines (HMs) to FOLFOX 4 for advanced colorectal cancer (ACRC) in terms of tumor response rate (tRR), survival, quality of life and reduction in adverse events (AEs). Seven electronic databases were searched for randomized controlled trials (RCTs) of FOLFOX4 combined with HMs compared to FOLFOX4 alone. Outcome data for 13 randomized controlled trials were analysed using Review Manager 5.1. Risk of bias for objective outcomes including tumor response and survival was judged as low. Publication bias was not evident. Meta-analyses found the addition of HMs improved tRR (RR 1.25, 95%CI 1.06-1.47, I2=0%), one year survival (RR 1.51, 95%CI 1.19-1.90, I2=0%) and quality of life in terms of Karnofsky Performance Status (KPS) gained (RR 1.84, 95%CI 1.54-2.19, I2=0%); alleviated grade 3 and 4 chemotherapy-related AEs for neutropenia (RR 0.33, 95%CI 0.18-0.60, I2=0%), nausea and vomiting (RR 0.34, 95%CI 0.17-0.67, I2=0%) and neurotoxicity (RR 0.39, 95%CI 0.15-1.00, I2=0%), compared to FOLFOX4 alone. The most frequently used herbs were Astragalus membranaceus, Panax ginseng, Atractylodes macrocephala, Poria cocos, Coix lachryma-jobi and Sophora flavescens. In experimental studies, each of these herbs has shown actions that could have contributed to improved tumor response.
Subject Oncology and Carcinogenesis not elsewhere classified
Traditional Chinese Medicine and Treatments
Keyword(s) Colorectal cancer
FOLFOX
herbal medicine
tumor response
quality of life
meta-analysis
DOI - identifier 10.1002/ptr.5092
Copyright notice © 2013 John Wiley & Sons, Ltd.
ISSN 0951-418X
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