Stabilization of polyoxometalates on gold nanoparticles surface using amino acid linker to control their toxicity

Daima, H, Periasamy, S, Shukla, R, Bhargava, S and Bansal, V 2012, 'Stabilization of polyoxometalates on gold nanoparticles surface using amino acid linker to control their toxicity', in C. Davies (ed.) Proceedings of Chemeca 2012: Quality of life through chemical engineering, Wellington, New Zealand, 23-26 September 2012, pp. 1628-1634.


Document type: Conference Paper
Collection: Conference Papers

Title Stabilization of polyoxometalates on gold nanoparticles surface using amino acid linker to control their toxicity
Author(s) Daima, H
Periasamy, S
Shukla, R
Bhargava, S
Bansal, V
Year 2012
Conference name Chemeca 2012: Quality of life through chemical engineering
Conference location Wellington, New Zealand
Conference dates 23-26 September 2012
Proceedings title Proceedings of Chemeca 2012: Quality of life through chemical engineering
Editor(s) C. Davies
Publisher Engineers Australia
Place of publication ACT, Australia
Start page 1628
End page 1634
Total pages 7
Abstract Polyoxometalates (POMs) have been used for antibacterial, antiviral and anticancer applications in in-vitro toxicological studies. These POMs induce oxidative stress at the cell surface and in the cytoplasm. However their instability at physiological pH, non specific binding, and high toxicity limits their direct application in biology and medicine. To circumvent that, we have developed a strategy to anchor them on a biocompatible carrier such as gold nanoparticles (AuNPs) by using an amino acid linker to regulate their stability and toxicity. AuNPs were synthesized by the reduction of gold ions using aspartic acid as reducing agent. These AuNPs were surface functionalized with cationic amino acid lysine to strongly anchor POMs. Subsequently, these lysine functionalized gold nanoparticles (AuNPsLys) were further modified with two POMs such as phosphotungstic acid (PTA) or phosphomolybdic acid (PMA). UV-visible, RAMAN, XPS, DLS and TEM studies were carried out to characterize these nanomaterials. Currently, we are exploring antibacterial, anticancer and other biological applications of these functionalized nanomaterials.
Subjects Nanobiotechnology
Copyright notice © 2012 Engineers Australia
ISBN 9781922107596
Versions
Version Filter Type
Access Statistics: 134 Abstract Views  -  Detailed Statistics
Created: Tue, 02 Sep 2014, 07:47:00 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us