Comparisons of halogenated ß-nitrostyrenes as antimicrobial agents

Cornell, H, Nguyen, T, Nicoletti, A, Jackson, N and Hugel, H 2014, 'Comparisons of halogenated ß-nitrostyrenes as antimicrobial agents', Applied Sciences, vol. 4, no. 3, pp. 380-389.


Document type: Journal Article
Collection: Journal Articles

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Title Comparisons of halogenated ß-nitrostyrenes as antimicrobial agents
Author(s) Cornell, H
Nguyen, T
Nicoletti, A
Jackson, N
Hugel, H
Year 2014
Journal name Applied Sciences
Volume number 4
Issue number 3
Start page 380
End page 389
Total pages 10
Publisher MDPI AG
Abstract The influence of three types of halogen-substituted E-ß-methyl-ß-nitrostyrenes (such as Compounds B, D, H) to overcome bacterial activity that is currently a significant health threat was studied. The evaluations of their bio-potency was measured and related to their structure and activity relationships for the purposes of serving to inhibit and overcoming resistant microorganisms. In particular, fluorine-containing ß-nitrostyrenes were found to be highly active antimicrobial agents. The addition of the ß-bromo group enhanced the antibacterial activity significantly. Our work has illustrated that halogen substituents at both the 4-position in the aromatic ring and also at the ß-position on the alkene side chain of nitropropenyl arenes enhanced the antimicrobial activity of these compounds.
Subject Biologically Active Molecules
Natural Products Chemistry
Keyword(s) antimicrobial agents
medicinal chemistry
halogenated ß-methyl-ß-nitrostyrenes
Minimum Inhibitory Concentration
DOI - identifier 10.3390/app4030380
Copyright notice 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
ISSN 2076-3417
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