Myelin inhibitors of neurite outgrowth in spinal cord injury

Azari, M and Petratos, S 2012, 'Myelin inhibitors of neurite outgrowth in spinal cord injury' in Morganti-Kossmann,C. Raghupathi,M and Mass,A (ed.) Traumatic Brain and Spinal Cord Injury : Challenges and Developments, Cambridge University Press, Cambridge,UK, pp. 264-271.


Document type: Book Chapter
Collection: Book Chapters

Title Myelin inhibitors of neurite outgrowth in spinal cord injury
Author(s) Azari, M
Petratos, S
Year 2012
Title of book Traumatic Brain and Spinal Cord Injury : Challenges and Developments
Publisher Cambridge University Press
Place of publication Cambridge,UK
Editor(s) Morganti-Kossmann,C. Raghupathi,M and Mass,A
Start page 264
End page 271
Subjects Medical Physiology not elsewhere classified
Summary Molecular mechanisms that regulate axonal regrowth after injury or disease in the central nervous system (CNS) constitute a current focus of research aimed at improving neurological function. Limiting demyelination following injury in the spinal cord can enhance endogenous signaling mechanisms driving axonal regxowth [I, 2]. Moreover, current evidence defines pharmacological blockade of the myelin-associated inhibitory factors (MAIFs) as a means of enhancing regeneration in the CNS [3- 6]. This chapter will deal with the current understanding of why there is regenerative failure of transected axons in acute spinal cord injury (SCI) and how the molecules that drive axonal degeneration can be targeted to limit degeneration and promote axonal regrowth.
Copyright notice © 2012 Cambridge University Press
ISBN 9781107007437
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