Avenins from different cultivars of oats elicit response by coeliac peripheral lymphocytes

Marco, S, Rita, D, Maialetti, F, De Vincenzi, A, Calcaterra, R, Cornell, H and De Vincenzi, M 2007, 'Avenins from different cultivars of oats elicit response by coeliac peripheral lymphocytes', Scandinavian Journal Of Gastroenterology, vol. 42, no. 11, pp. 1302-1305.

Document type: Journal Article
Collection: Journal Articles

Title Avenins from different cultivars of oats elicit response by coeliac peripheral lymphocytes
Author(s) Marco, S
Rita, D
Maialetti, F
De Vincenzi, A
Calcaterra, R
Cornell, H
De Vincenzi, M
Year 2007
Journal name Scandinavian Journal Of Gastroenterology
Volume number 42
Issue number 11
Start page 1302
End page 1305
Total pages 3
Publisher Taylor and Francis
Abstract Objective. The avoidance of oats in coeliac patients is still controversial. If oats is confirmed to be safe, it would be a valuable component and offer more variation in a gluten-free diet. The aim of this work was to evaluate whether avenins from different varieties of oats show different abilities in the activation of coeliac peripheral lymphocytes. Material and methods. In order to assess whether the immunogenic effect of oats varies according to the cultivar, peripheral lymphocytes from 10 coeliac children were exposed to avenins from four different oats varieties: Lampton, Astra, Ava and Nave. Lymphocyte proliferation and interferon-gamma (IFN-?) release in the culture medium were measured as indexes of immune activation. Results. All the varieties of oats tested were immunogenic, with Lampton and Ava avenins inducing lymphocyte activation similar to that activated by wheat gliadin, while Astra and Nave avenins showed less immunogenicity, but still with a measurable effect. Conclusions. There are still concerns about the suitability of including oats in a gluten-free diet. Coeliac patients consuming oats-containing food should be carefully monitored, until there is more evidence to show the safety of oats and varieties of low-toxicity oats.
Subject Enzymes
DOI - identifier 10.1080/00365520701420750
Copyright notice © 2007 Taylor and Francis
ISSN 0036-5521
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Citation counts: TR Web of Science Citation Count  Cited 39 times in Thomson Reuters Web of Science Article | Citations
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