Evaluation of the RRM model using dehydrogenase protein as example

Pirogova, E, Fang, Q and Cosic, I 2003, 'Evaluation of the RRM model using dehydrogenase protein as example', in Proceedings of 5th IFAC Symposium on Modelling and Control in Biomedical Systems, Melbourne, Australia, 21-23 August 2003.


Document type: Conference Paper
Collection: Conference Papers

Title Evaluation of the RRM model using dehydrogenase protein as example
Author(s) Pirogova, E
Fang, Q
Cosic, I
Year 2003
Conference name Symposium on Modelling and Control in Biomedical Systems
Conference location Melbourne, Australia
Conference dates 21-23 August 2003
Proceedings title Proceedings of 5th IFAC Symposium on Modelling and Control in Biomedical Systems
Publisher International Federation of Automatic Control
Place of publication Laxenburg, Austria
Abstract Enzymes are crucial in accelerating metabolic reactions in the living organism. Dehydrogenases are the enzymes that catalyze a variety of oxidation-reduction reactions within the cells. In this study we have performed the structure-function analysisof dehydrogenases using the Resonant Recognition Model (RRM) based on digital signal processing (DSP) methods: Inverse Fourier Transform (IFT) and Continuous Wavelet Transform (CWT). Here we have determined the characteristic frequencies and the "hotspot" amino acids, and also predicted the location of protein's active site(s). The results of this computational analysis provide new insights into the structure-function relationships of the dehydrogenase proteins.
Subjects Biomedical Engineering not elsewhere classified
Copyright notice © 2003 IFAC
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