Investigating the interaction between oncogene and tumor suppressor protein

Pirogova, E, Akay, M and Cosic, I 2006, 'Investigating the interaction between oncogene and tumor suppressor protein', in Proceedings of ITAB 2006, Ioannina, Greece, 26-28 October 2006.

Document type: Conference Paper
Collection: Conference Papers

Title Investigating the interaction between oncogene and tumor suppressor protein
Author(s) Pirogova, E
Akay, M
Cosic, I
Year 2006
Conference name ITAB
Conference location Ioannina, Greece
Conference dates 26-28 October 2006
Proceedings title Proceedings of ITAB 2006
Publisher IEEE
Place of publication Ioannina, Greece
Abstract It is known that cancer develops when cells in a part of the body begin to grow out of control. Because cancer cells continue to grow and divide with no order, they never differentiate into the specific tissue, and thus, they are functionally different from normal cells. However, there are some genes that help to prevent cells' malignant behavior, and therefore, are referred to as tumor suppressor genes. Here, we have investigated the structural and functional relationships of p53, oncogene and interleukin 2 (IL2) proteins using the resonant recognition model (RRM), a physico-mathematical approach based on digital signal processing methods. In addition, using the RRM concepts, we have designed the peptide analoges that would exhibit tumor-suppression-like activity and be used in anticancer vaccine development.
Subjects Biomaterials
DOI - identifier 10.1109/TITB.2008.2003338
Copyright notice © 2006 IEEE
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