Synthesis, characterization and cytotoxic activity of palladium (II) carbohydrate complexes

Deepthi, S, Trivedi, R, Sujitha, P, Kumar, G, Sridhar, B and Bhargava, S 2012, 'Synthesis, characterization and cytotoxic activity of palladium (II) carbohydrate complexes', Journal of Chemical Sciences, vol. 124, no. 6, pp. 1405-1413.


Document type: Journal Article
Collection: Journal Articles

Title Synthesis, characterization and cytotoxic activity of palladium (II) carbohydrate complexes
Author(s) Deepthi, S
Trivedi, R
Sujitha, P
Kumar, G
Sridhar, B
Bhargava, S
Year 2012
Journal name Journal of Chemical Sciences
Volume number 124
Issue number 6
Start page 1405
End page 1413
Total pages 9
Publisher Indian Academy of Sciences
Abstract Carbohydrate containing pyridyl triazole ligands, 5-deoxy-1,2-O- isopropylidene-5-(4-(2-pyridyl)-1H-1,2,3-triazole-1-yl)-α-D-xylofuranose (2a), 3-O-Benzyl-5-deoxy-1,2-O-isopropylidene-5-(4-(2-pyridyl)-1H-1,2,3-triazol- 1-yl)-α-D-xylofuranose (2b), methyl-5-deoxy-2,3-O-isopropylidene-5-(4-(2- pyridyl)-1H-1,2,3-triazol-1-yl)-β-D-ribofuranoside, (2c) and 6-deoxy-1,2:3,4-di-O-isopropylidene-6-(4-(2-pyridyl)-1H-1,2,3-triazol-1-yl) -α-D-galactopyranose (2d) were prepared by the 'click' reaction of 2-ethynyl pyridine with the corresponding azides. The palladium complexes were synthesised by the reaction of pyridyl triazole ligands with [Pd(COD)Cl 2] in dichloromethane. All the compounds were characterised by NMR, IR, mass and elemental analysis. Structural characterization of the ligand 2a was done by X-ray crystallography. The ligands and complexes were tested for their cytotoxic activity on different cell lines like A549 (human alveolar adenocarcinoma cells), Neuro2a (mouse neuroblastoma cells), HeLa (cervical carcinoma cancer cells), MDA-MB-231 (human breast adenocarcinoma cells) and MCF7 (human breast adenocarcinoma cells). The complexes showed considerable cytotoxicity while the ligands were non-toxic on the tested cell lines
Subject Organometallic Chemistry
Keyword(s) Carbohydrate
cytotoxicity
palladium complexes
pyridyl triazole
DOI - identifier 10.1007/s12039-012-0340-3
Copyright notice © Indian Academy of Sciences 2012
ISSN 0974-3626
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