Role of alveolar macrophages in chronic obstructive pulmonary disease

Vlahos, R and Bozinovski, S 2014, 'Role of alveolar macrophages in chronic obstructive pulmonary disease', Frontiers in Immunology, vol. 5, 435, pp. 1-7.


Document type: Journal Article
Collection: Journal Articles

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Title Role of alveolar macrophages in chronic obstructive pulmonary disease
Author(s) Vlahos, R
Bozinovski, S
Year 2014
Journal name Frontiers in Immunology
Volume number 5
Article Number 435
Start page 1
End page 7
Total pages 7
Publisher Frontiers Research Foundation
Abstract Alveolar macrophages (AMs) represent a unique leukocyte population that responds to airborne irritants and microbes. This distinct microenvironment coordinates the maturation of long-lived AMs, which originate from fetal blood monocytes and self-renew through mechanisms dependent on GM-CSF and CSF-1 signaling. Peripheral blood monocytes can also replenish lung macrophages; however, this appears to occur in a stimuli specific manner. In addition to mounting an appropriate immune response during infection and injury, AMs actively coordinate the resolution of inflammation through efferocytosis of apoptotic cells. Any perturbation of this process can lead to deleterious responses. In chronic obstructive pulmonary disease (COPD), there is an accumulation of airway macrophages that do not conform to the classic M1/M2 dichotomy. There is also a skewed transcriptome profile that favors expression of wound-healing M2 markers, which is reflective of a deficiency to resolve inflammation. Endogenous mediators that can promote an imbalance in inhibitory M1 vs. healing M2 macrophages are discussed, as they are the plausible mechanisms underlying why AMs fail to effectively resolve inflammation and restore normal lung homeostasis in COPD.
Subject Immunology not elsewhere classified
Keyword(s) alveolar macrophage
chronic obstructive pulmonary disease
efferocytosis
lung inflammation
oxidative stress
resolution
DOI - identifier 10.3389/fimmu.2014.00435
Copyright notice © 2014 Vlahos and Bozinovski
ISSN 1664-3224
Additional Notes Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
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