HDAC inhibitors in HIV

Wightman, F, Ellenberg, P, Churchill, M and Lewin, S 2012, 'HDAC inhibitors in HIV', Immunology and Cell Biology, vol. 90, no. 1, pp. 47-54.


Document type: Journal Article
Collection: Journal Articles

Title HDAC inhibitors in HIV
Author(s) Wightman, F
Ellenberg, P
Churchill, M
Lewin, S
Year 2012
Journal name Immunology and Cell Biology
Volume number 90
Issue number 1
Start page 47
End page 54
Total pages 8
Publisher Nature Publishing Group
Abstract Combination antiretroviral therapy (cART) has led to a very substantial reduction in morbidity and mortality in HIV-infected patients; however, cART alone is unable to cure HIV and therapy is lifelong. Therefore, a new strategy to cure HIV is urgently needed. There is now a concerted effort from scientists, clinicians and funding agencies to identify ways to achieve either a functional cure (long-term control of HIV in the absence of cART) or a sterilizing cure (elimination of all HIV-infected cells). Multiple strategies aiming at achieving a cure for HIV are currently being investigated, including both pharmacotherapy and gene therapy. In this review, we will review the rationale as well as in vitro and clinical trial data that support the role of histone deacetylase inhibitors as one approach to cure HIV.
Subject Virology
Medical Biochemistry: Nucleic Acids
Keyword(s) cure
HDAC inhibitor
HIV
latency
transcription
DOI - identifier 10.1038/icb.2011.95
Copyright notice © 2012 Australasian Society for Immunology Inc. All rights reserved.
ISSN 0818-9641
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