In vitro tests indicate that certain varieties of oats may be harmful to patients with coeliac disease

Marco, S, Dessi, M, De Vincenzi, M and Cornell, H 2007, 'In vitro tests indicate that certain varieties of oats may be harmful to patients with coeliac disease', Journal of Gastroenterology and Hepatology, vol. 22, pp. 528-531.


Document type: Journal Article
Collection: Journal Articles

Title In vitro tests indicate that certain varieties of oats may be harmful to patients with coeliac disease
Author(s) Marco, S
Dessi, M
De Vincenzi, M
Cornell, H
Year 2007
Journal name Journal of Gastroenterology and Hepatology
Volume number 22
Start page 528
End page 531
Total pages 3
Publisher Blackwell Publishing
Abstract BACKGROUND - The presence of oats in gluten-free diet is controversial. The aim of this work is to evaluate if different varieties of oats exert different toxicity in coeliac disease. METHODS - Three varieties of oats were tested by two in vitro assay based on the known ability of peptic-tryptic digests of coeliac-active proteins to agglutinate K562 cells and to disrupt lysosomes, respectively. RESULTS - Avenins from the Italian variety Astra and the Australian variety Mortlook were much more active than the Australian variety Lampton. Gliadin, digested in the same way, certainly displayed more activity than all three avenins, but rice (var. Roma) did not have measurable activity. CONCLUSIONS - The results indicate that some varieties of oats may be potentially harmful to individuals with coeliac disease and therefore should be excluded from the gluten-free diet required to maintain good health in coeliac disease. It is important to realize that constant, small amounts of active proteins in the diet, such as certain avenins, may prevent complete recovery of the intestinal mucosa in this disease.
Subject Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
DOI - identifier 10.1111/j.1440-1746.2006.04512.x
Copyright notice © 2007 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
ISSN 0815-9319
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 27 times in Scopus Article | Citations
Altmetric details:
Access Statistics: 129 Abstract Views  -  Detailed Statistics
Created: Mon, 18 Jan 2010, 09:17:05 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us