Exogenous folates stimulate growth and budding of Candida glabrata

Porzoor, A and Macreadie, I 2015, 'Exogenous folates stimulate growth and budding of Candida glabrata', Microbial Cell, vol. 2, no. 5, pp. 163-167.

Document type: Journal Article
Collection: Journal Articles

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Title Exogenous folates stimulate growth and budding of Candida glabrata
Author(s) Porzoor, A
Macreadie, I
Year 2015
Journal name Microbial Cell
Volume number 2
Issue number 5
Start page 163
End page 167
Total pages 5
Publisher Shared Science Publishers OG
Abstract Folate, vitamin B9, is well recognized as being essential for cell growth. The utilization of folate is common to all cells, but the source of it may be quite different. For example, mammalian cells depend on exogenous uptake of folates, while plants and microbes can synthesize them. There has been little consideration of uptake of folate in microbial cells, and studies on the effects of folates in mammalian cells, where conditions are restricted. This study shows that exogenous folates (folic acid or folinic acid), causes Candida glabrata cells suspended in water alone to undergo two cycles of cell division and to form multiple buds. The effect was limited to cells in the stationary phase and more profound in quiescent cells. These data indicate a novel response of yeast to folates that may increase the utility of yeast as a model to study folate transport and signaling.
Subject Cell Development, Proliferation and Death
Keyword(s) Candida glabrata
Unscheduled cell division
DOI - identifier 10.15698/mic2015.05.202
Copyright notice © 2015 Porzoor and Macreadie. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
ISSN 2311-2638
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