Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis

Jenkins, T, Nguyen, J, Polglaze, K and Bertrand, P 2016, 'Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis', Nutrients, vol. 8, no. 1, 56, pp. 1-15.


Document type: Journal Article
Collection: Journal Articles

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Title Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis
Author(s) Jenkins, T
Nguyen, J
Polglaze, K
Bertrand, P
Year 2016
Journal name Nutrients
Volume number 8
Issue number 1
Article Number 56
Start page 1
End page 15
Total pages 15
Publisher M D P I AG
Abstract The serotonergic system forms a diffuse network within the central nervous system and plays a significant role in the regulation of mood and cognition. Manipulation of tryptophan levels, acutely or chronically, by depletion or supplementation, is an experimental procedure for modifying peripheral and central serotonin levels. These studies have allowed us to establish the role of serotonin in higher order brain function in both preclinical and clinical situations and have precipitated the finding that low brain serotonin levels are associated with poor memory and depressed mood. The gut-brain axis is a bi-directional system between the brain and gastrointestinal tract, linking emotional and cognitive centres of the brain with peripheral functioning of the digestive tract. An influence of gut microbiota on behaviour is becoming increasingly evident, as is the extension to tryptophan and serotonin, producing a possibility that alterations in the gut may be important in the pathophysiology of human central nervous system disorders. In this review we will discuss the effect of manipulating tryptophan on mood and cognition, and discuss a possible influence of the gut-brain axis.
Subject Central Nervous System
Peripheral Nervous System
Keyword(s) Gut-brain axis
Mood and cognition
Serotonin
Tryptophan
DOI - identifier 10.3390/nu8010056
Copyright notice © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
ISSN 2072-6643
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