Resistin, an adipokine with non-generalized actions on sympathetic nerve activity

Badoer, E, Kosari, S and Stebbing, M 2015, 'Resistin, an adipokine with non-generalized actions on sympathetic nerve activity', Frontiers in Physiology, vol. 6, 321, pp. 1-9.


Document type: Journal Article
Collection: Journal Articles

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Title Resistin, an adipokine with non-generalized actions on sympathetic nerve activity
Author(s) Badoer, E
Kosari, S
Stebbing, M
Year 2015
Journal name Frontiers in Physiology
Volume number 6
Article Number 321
Start page 1
End page 9
Total pages 9
Publisher Frontiers Research Foundation
Abstract The World Health Organization has called obesity a global epidemic. There is a strong association between body weight gain and blood pressure. A major determinant of blood pressure is the level of activity in sympathetic nerves innervating cardiovascular organs. A characteristic of obesity, in both humans and in animal models, is an increase in sympathetic nerve activity to the skeletal muscle vasculature and to the kidneys. Obesity is now recognized as a chronic, low level inflammatory condition, and pro-inflammatory cytokines are elevated including those produced by adipose tissue. The most well-known adipokine released from fat tissue is leptin. The adipokine, resistin, is also released from adipose tissue. Resistin can act in the central nervous system to influence the sympathetic nerve activity. Here, we review the effects of resistin on sympathetic nerve activity and compare them with leptin. We build an argument that resistin and leptin may have complex interactions. Firstly, they may augment each other as both are excitatory on sympathetic nerves innervating cardiovascular organs; In contrast, they could antagonize each other's actions on brown adipose tissue, a key metabolic organ. These interactions may be important in conditions in which leptin and resistin are elevated, such as in obesity.
Subject Neurosciences not elsewhere classified
Keyword(s) energy metabolism
resistin. leptin. sympathetic nerve activity
thermogenesis. brown adipose tissue. cardiovascular function
DOI - identifier 10.3389/fphys.2015.00321
Copyright notice Copyright © 2015 Badoer, Kosari and Stebbing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
ISSN 1664-042X
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