Reliable genotypic tropism tests for the major HIV-1 subtypes

Cashin, K, Gray, L, Harvey, K, Perez-Bercoff, D, Lee, G, Sterjovski, J, Roche, M, Demarest, J, Drummond, F, Harrigan, R, Churchill, M and Gorry, P 2015, 'Reliable genotypic tropism tests for the major HIV-1 subtypes', Scientific Reports, vol. 5, 8543, pp. 1-8.


Document type: Journal Article
Collection: Journal Articles

Title Reliable genotypic tropism tests for the major HIV-1 subtypes
Author(s) Cashin, K
Gray, L
Harvey, K
Perez-Bercoff, D
Lee, G
Sterjovski, J
Roche, M
Demarest, J
Drummond, F
Harrigan, R
Churchill, M
Gorry, P
Year 2015
Journal name Scientific Reports
Volume number 5
Article Number 8543
Start page 1
End page 8
Total pages 8
Publisher Nature Publishing Group
Abstract Over the past decade antiretroviral drugs have dramatically improved the prognosis for HIV-1 infected individuals, yet achieving better access to vulnerable populations remains a challenge. The principal obstacle to the CCR5-antagonist, maraviroc, from being more widely used in anti-HIV-1 therapy regimens is that the pre-treatment genotypic œ tropism tests to determine virus susceptibility to maraviroc have been developed primarily for HIV-1 subtype B strains, which account for only 10% of infections worldwide. We therefore developed PhenoSeq, a suite of HIV-1 genotypic tropism assays that are highly sensitive and specific for establishing the tropism of HIV-1 subtypes A, B, C, D and circulating recombinant forms of subtypes AE and AG, which together account for 95% of HIV-1 infections worldwide. The PhenoSeq platform will inform the appropriate use of maraviroc and future CCR5 blocking drugs in regions of the world where non-B HIV-1 predominates, which are burdened the most by the HIV-1 pandemic.
Subject Clinical Sciences not elsewhere classified
Keyword(s) Immunodeficiency-Virus Type-1
Coreceptor Usage Prediction
Treatment-Experienced Patients
Treatment-Naive Patients
Amino-Acid Changes
Virological Response
V3 Loop
Hiv-1-Infected Individuals
Phenotype Prediction
Evolving Epidemic
DOI - identifier 10.1038/srep08543
Copyright notice This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
ISSN 2045-2322
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