Reliable genotypic tropism tests for the major HIV-1 subtypes

Cashin, K, Gray, L, Harvey, K, Perez-Bercoff, D, Lee, G, Sterjovski, J, Roche, M, Demarest, J, Drummond, F, Harrigan, R, Churchill, M and Gorry, P 2015, 'Reliable genotypic tropism tests for the major HIV-1 subtypes', Scientific Reports, vol. 5, 8543, pp. 1-8.

Document type: Journal Article
Collection: Journal Articles

Title Reliable genotypic tropism tests for the major HIV-1 subtypes
Author(s) Cashin, K
Gray, L
Harvey, K
Perez-Bercoff, D
Lee, G
Sterjovski, J
Roche, M
Demarest, J
Drummond, F
Harrigan, R
Churchill, M
Gorry, P
Year 2015
Journal name Scientific Reports
Volume number 5
Article Number 8543
Start page 1
End page 8
Total pages 8
Publisher Nature Publishing Group
Abstract Over the past decade antiretroviral drugs have dramatically improved the prognosis for HIV-1 infected individuals, yet achieving better access to vulnerable populations remains a challenge. The principal obstacle to the CCR5-antagonist, maraviroc, from being more widely used in anti-HIV-1 therapy regimens is that the pre-treatment genotypic œ tropism tests to determine virus susceptibility to maraviroc have been developed primarily for HIV-1 subtype B strains, which account for only 10% of infections worldwide. We therefore developed PhenoSeq, a suite of HIV-1 genotypic tropism assays that are highly sensitive and specific for establishing the tropism of HIV-1 subtypes A, B, C, D and circulating recombinant forms of subtypes AE and AG, which together account for 95% of HIV-1 infections worldwide. The PhenoSeq platform will inform the appropriate use of maraviroc and future CCR5 blocking drugs in regions of the world where non-B HIV-1 predominates, which are burdened the most by the HIV-1 pandemic.
Subject Clinical Sciences not elsewhere classified
Keyword(s) Immunodeficiency-Virus Type-1
Coreceptor Usage Prediction
Treatment-Experienced Patients
Treatment-Naive Patients
Amino-Acid Changes
Virological Response
V3 Loop
Hiv-1-Infected Individuals
Phenotype Prediction
Evolving Epidemic
DOI - identifier 10.1038/srep08543
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ISSN 2045-2322
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