The role of ion channels in microglial activation and proliferation - a complex interplay between ligand-gated ion channels, K+ channels, and intracellular Ca2+

Stebbing, M, Cottee, J and Rana, I 2015, 'The role of ion channels in microglial activation and proliferation - a complex interplay between ligand-gated ion channels, K+ channels, and intracellular Ca2+', Frontiers in Immunology, vol. 6, no. OCT, 497, pp. 1-7.


Document type: Journal Article
Collection: Journal Articles

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Title The role of ion channels in microglial activation and proliferation - a complex interplay between ligand-gated ion channels, K+ channels, and intracellular Ca2+
Author(s) Stebbing, M
Cottee, J
Rana, I
Year 2015
Journal name Frontiers in Immunology
Volume number 6
Issue number OCT
Article Number 497
Start page 1
End page 7
Publisher Frontiers Research Foundation
Abstract Microglia are often referred to as the immune cells of the brain. They are most definitely involved in immune responses to invading pathogens and inflammatory responses to tissue damage. However, recent results suggest microglia are vital for normal functioning of the brain. Neuroinflammation, as well as more subtle changes, in microglial function has been implicated in the pathogenesis of many brain diseases and disorders. Upon sensing alterations in their local environment, microglia change their shape and release factors that can modify the excitability of surrounding neurons. During neuroinflammation, microglia proliferate and release NO, reactive oxygen species, cytokines and chemokines. If inflammation resolves then their numbers normalize again via apoptosis. Microglia express a wide array of ion channels and different types are implicated in all of the cellular processes listed above. Modulation of microglial ion channels has shown great promise as a therapeutic strategy in several brain disorders. In this review, we discuss recent advances in our knowledge of microglial ion channels and their roles in responses of microglia to changes in the extracellular milieu.
Subject Immunology not elsewhere classified
Cellular Nervous System
Keyword(s) Ion channels
K+ channels
Microglia
Neuroinflammation
P2X receptors
DOI - identifier 10.3389/fimmu.2015.00497
Copyright notice © 2015 Stebbing, Cottee and Rana. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
ISSN 1664-3224
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