Meta-analysis of oxaliplatin-based chemotherapy combined with traditional medicines for colorectal cancer: Contributions of specific plants to tumor response

Chen, M, May, B, Zhou, I, Xue, C and Zhang, A 2016, 'Meta-analysis of oxaliplatin-based chemotherapy combined with traditional medicines for colorectal cancer: Contributions of specific plants to tumor response', Integrative Cancer Therapies, vol. 15, no. 1, pp. 40-59.


Document type: Journal Article
Collection: Journal Articles

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Title Meta-analysis of oxaliplatin-based chemotherapy combined with traditional medicines for colorectal cancer: Contributions of specific plants to tumor response
Author(s) Chen, M
May, B
Zhou, I
Xue, C
Zhang, A
Year 2016
Journal name Integrative Cancer Therapies
Volume number 15
Issue number 1
Start page 40
End page 59
Total pages 20
Publisher Sage Publications
Abstract This meta-analysis evaluates the clinical evidence for the addition of traditional medicines (TMs) to oxaliplatin-based regimens for colorectal cancer (CRC) in terms of tumor response rate (TRR). Eight electronic databases were searched for randomized controlled trials of oxaliplatin-based chemotherapy combined with TMs compared to the same oxaliplatin-based regimen. Data on TRR from 42 randomized controlled trials were analyzed using Review Manager 5.1. Studies were conducted in China or Japan. Publication bias was not evident. The meta-analyses suggest that the combination of the TMs with oxaliplatin-based regimens increased TRR in the palliative treatment of CRC (risk ratio [RR] 1.31 [1.20-1.42], I(2) = 0%). Benefits were evident for both injection products (RR 1.36 [1.18-1.57], I(2) = 0%) and orally administered TMs (RR 1.27 [1.15-1.41], I(2) = 0%). Further sensitivity analysis of specific plant-based TMs found that Paeonia, Curcuma, and Sophora produced consistently higher contributions to the RR results. Compounds in each of these TMs have shown growth-inhibitory effects in CRC cell-line studies. Specific combinations of TMs appeared to produce higher contributions to TRR than the TMs individually. Notable among these was the combination of Hedyotis, Astragalus, and Scutellaria.
Subject Traditional Chinese Medicine and Treatments
Keyword(s) Colorectal cancer
Oxaliplatin
Traditional medicine
Tumor response
Meta-analysis
Synergistic action
DOI - identifier 10.1177/1534735415596424
Copyright notice © The Author(s)
ISSN 1534-7354
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