Oral Chinese herbal medicine versus placebo for psoriasis vulgaris: A systematic review

Parker, S, Zhang, S, Yu, J, Lu, C, Zhang, A and Xue, C 2017, 'Oral Chinese herbal medicine versus placebo for psoriasis vulgaris: A systematic review', Journal of Dermatological Treatment, vol. 28, no. 1, pp. 21-31.


Document type: Journal Article
Collection: Journal Articles

Title Oral Chinese herbal medicine versus placebo for psoriasis vulgaris: A systematic review
Author(s) Parker, S
Zhang, S
Yu, J
Lu, C
Zhang, A
Xue, C
Year 2017
Journal name Journal of Dermatological Treatment
Volume number 28
Issue number 1
Start page 21
End page 31
Total pages 10
Publisher Taylor and Francis
Abstract Objectives: Psoriasis is a chronic inflammatory skin disorder and the efficacy and safety of Chinese herbal medicine (CHM) treatments is unclear. This review evaluates oral CHM for psoriasis vulgaris clinical trial evidence. Design: The Cochrane Library, PubMed, EMBASE, CINAHL, AMED, CBM, CNKI, CQVIP and Wanfang databases were searched from inception to June 2015. Randomised controlled trials (RCTs) of oral CHM compared to placebo data were included and analysed using Review Manager 5.2. Results: Seven studies were included, no study utilised identical CHM intervention. Four studies data were subgrouped (decoction or capsule/pill) and pooled in meta-analysis to evaluate treatment effective rate for PASI60 or above (RR: 2.74 [0.92, 8.21] I2 = 65%). Another five studies were subgrouped and evaluated for PASI score change, (MD -7.00 [-10.74, -3.27] I2 = 98%). Only one study presented Dermatology Life Quality Index data, which favoured CHM (MD: -4.08 [-7.56, -0.60]). Two studies presented data on psoriasis-related inflammatory cell-signalling protein tumour necrosis factor-a (TNF-a) (MD: -4.92 [-5.31, -4.53]). No serious adverse events were reported. Conclusion: While CHMs appear to be safe and may have benefit for psoriasis, variation between CHM interventions, outcome measures and the quality of included studies limit the conclusions of this review. Further rigorous RCTs utilising reliable, validated symptom and QoL outcome measures are recommended.
Subject Traditional Chinese Medicine and Treatments
Dermatology
Keyword(s) control
herb
Psoriasis
random
review
trial
DOI - identifier 10.1080/09546634.2016.1178377
Copyright notice © 2016 Informa UK Limited, trading as Taylor and Francis Group
ISSN 0954-6634
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