Potential of in vivo real-time gastric gas profiling: A pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model

Ou, J, Cottrell, J, Ha, N, Pillai, N, Yao, C, Berean, K, Ward, S, Grando, D, Muir, J, Harrison, C, Wijesiriwardana, U, Dunshea, F, Gibson, P and Kalantar Zadeh, K 2016, 'Potential of in vivo real-time gastric gas profiling: A pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model', Scientific Reports, vol. 6, 33387, pp. 1-9.


Document type: Journal Article
Collection: Journal Articles

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Title Potential of in vivo real-time gastric gas profiling: A pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model
Author(s) Ou, J
Cottrell, J
Ha, N
Pillai, N
Yao, C
Berean, K
Ward, S
Grando, D
Muir, J
Harrison, C
Wijesiriwardana, U
Dunshea, F
Gibson, P
Kalantar Zadeh, K
Year 2016
Journal name Scientific Reports
Volume number 6
Article Number 33387
Start page 1
End page 9
Total pages 9
Publisher Nature Publishing Gorup
Abstract Gastroenterologists are still unable to differentiate between some of the most ordinary disorders of the gut and consequently patients are misdiagnosed. We have developed a swallowable gas sensor capsule for addressing this. The gases of the gut are the by-product of the fermentation processes during digestion, affected by the gut state and can consequently provide the needed information regarding the health of the gut. Here we present the first study on gas sensor capsules for revealing the effect of a medical supplement in an animal (pig) model. We characterise the real-time alterations of gastric-gas in response to environmental heat-stress and dietary cinnamon and use the gas profiles for understanding the bio-physiological changes. Under no heat-stress, feeding increases gastric CO2 concentration, while dietary cinnamon reduces it due to decrease in gastric acid and pepsin secretion. Alternatively, heat-stress leads to hyperventilation in pigs, which reduces CO2 concentration and with the cinnamon treatment, CO2 diminishes even more, resulting in health improvement outcomes. Overall, a good repeatability in gas profiles is also observed. The model demonstrates the strong potential of real-time gas profiler in providing new physiological information that will impact understanding of therapeutics, presenting a highly reliable device for monitoring/diagnostics of gastrointestinal disorders.
Subject Microbiology not elsewhere classified
Clinical Microbiology
Medical Microbiology not elsewhere classified
DOI - identifier 10.1038/srep33387
Copyright notice © 2016 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
ISSN 2045-2322
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