Role of multidrug resistance associated proteins in drug development

Zhou, S 2008, 'Role of multidrug resistance associated proteins in drug development', Drug Discoveries and Therapeutics, vol. 2, no. 6, pp. 305-332.

Document type: Journal Article
Collection: Journal Articles

Title Role of multidrug resistance associated proteins in drug development
Author(s) Zhou, S
Year 2008
Journal name Drug Discoveries and Therapeutics
Volume number 2
Issue number 6
Start page 305
End page 332
Total pages 27
Publisher IACMHR and SDU-DDSC
Abstract The multidrug resistance associated proteins (MRP1, MRP2, MRP3, MRP4, MRP5, MRP6, MRP7, MRP8 and MRP9) belongs to the ATP-binding cassette superfamily (ABCC family) of transporters expressed differentially in the liver, kidney, intestine and blood-brain barrier. MRPs transport a structurally diverse array of endo- and xenobiotics and their metabolites (in particular conjugates) and are subject to induction and inhibition by a variety of compounds. An increased efflux of natural product anticancer drugs and other anticancer agents by MRPs in cancer cells is associated with tumor resistance. These transporting proteins play a role in the absorption, distribution and elimination of various compounds in the body. There are increased reports on the clinical impact of genetic mutations of genes encoding MRP1-9. Therefore, MRPs have an important role in drug development, and a better understanding of their function and regulating mechanism can help minimize and avoid drug toxicity, unfavourable drug-drug interactions, and to overcome drug resistance.
Subject Pharmacogenomics
Copyright notice © 2008 IACMHR and SDU-DDSC
ISSN 1881-784X
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