Gene Expression Biomarkers for Neurobehavioral Impairment From Total Sleep Deprivation

Uyhelji, H, Kupfer, D, White, V, Jackson, M, Van Dongen, H and Burian, D 2017, Gene Expression Biomarkers for Neurobehavioral Impairment From Total Sleep Deprivation, Office of Aerospace Medicine, Federal Aviation Administration, USA


Document type: Commissioned Reports
Collection: Commissioned Reports

Title of report Gene Expression Biomarkers for Neurobehavioral Impairment From Total Sleep Deprivation
Author(s) Uyhelji, H
Kupfer, D
White, V
Jackson, M
Van Dongen, H
Burian, D
Year of publication 2017
Publisher Office of Aerospace Medicine, Federal Aviation Administration
Place of publication USA
Subjects Gene Expression (incl. Microarray and other genome-wide approaches)
Abstract/Summary This study tests the hypothesis that gene expression responds to total SD, and can be related to neurobehavioral impairment measured by PVT lapses. The approach was one of biomarker discovery, sensu (MULLINGTON et al. 2016). Healthy human adults were recruited to the Sleep and Performance Research Center at Washington State University and acclimated with two nights of Baseline sleep for 10 h time-in-bed (TIB). Then subjects in the SD group underwent 62 h continuous wakefulness during an Experimental phase, followed by two Recovery nights of 10 h sleep opportunity. In contrast, individuals in the Control (C) group received 10 h TIB all six nights. Neurobehavioral impairment was assessed with the PVT, and blood was drawn for whole-transcriptome microarrays. Although gene expression may vary across fluid and tissue types, concordance as high as 80% has been reported between the transcriptome of blood and major tissues (LIEW et al. 2006; SUNDE 2010). A total of 212 genes were differentially expressed in response to Treatment, defined as a difference between SD and C subjects during the Experimental or Recovery phase. Also, the expression of 28 genes was associated with PVT lapses. Biological pathways and functions of the differentially expressed genes are discussed, as well as their utility as candidates for an operational sleep deprivation biomarker panel.
Commissioning body Federal Aviation Administration
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