Inhibition of respiration in yeast by 2-phenylethylamine

Phillips, J and Macreadie, I 2018, 'Inhibition of respiration in yeast by 2-phenylethylamine', Current Bioactive Compounds, vol. 14, pp. 67-69.


Document type: Journal Article
Collection: Journal Articles

Title Inhibition of respiration in yeast by 2-phenylethylamine
Author(s) Phillips, J
Macreadie, I
Year 2018
Journal name Current Bioactive Compounds
Volume number 14
Start page 67
End page 69
Total pages 3
Publisher Bentham Science Publishers
Abstract 2-phenylethylamine (2-PEA) is an organic neurotransmitter which belongs to a class of biogenic amines that are essential for regulation of cellular development, differentiation and homeostasis. This class of compounds have been reported to cause oxidative stress to neuronal cells in the brain, which have a high oxygen consumption rate, elevated iron content and low antioxidant concentration. 2-phenylethylamine can metabolise into hydroxyl radicals which have been found to be a direct cause of oxidative stress within cells. This study has explored the effects of 2-PEA on growth of various yeast strains in order to establish its capacity to cause toxicity through oxidative stress. Yeast cells are ideal for this application because, unlike mammalian cells, they do not require respiration to survive in the presence of glucose as the sole carbon source. 2-phenylethylamine was indeed found to be toxic to all strains of yeast where respiratory function was necessary. Almost all inhibitory effects could be reversed by antioxidants ascorbate and glutathione, indicating oxidative stress was the likely cause of toxicity through 2-PEA or one of its metabolites.
Subject Cell Development, Proliferation and Death
Keyword(s) 2-phenylethylamine
ascorbic acid
glutathione
mitochondrial respiratory function
reactive oxygen
yeast
DOI - identifier 10.2174/1573407213666161207115458
Copyright notice © 2018 Bentham Science Publishers
ISSN 1573-4072
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