Oxaliplatin-based chemotherapy combined with traditional medicines for neutropenia in colorectal cancer: A meta-analysis of the contributions of specific plants

Chen, M, May, B, Zhou, I, Sze, M, Xue, C and Zhang, A 2016, 'Oxaliplatin-based chemotherapy combined with traditional medicines for neutropenia in colorectal cancer: A meta-analysis of the contributions of specific plants', Critical Reviews in Oncology/Hematology, vol. 105, pp. 18-34.


Document type: Journal Article
Collection: Journal Articles

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Title Oxaliplatin-based chemotherapy combined with traditional medicines for neutropenia in colorectal cancer: A meta-analysis of the contributions of specific plants
Author(s) Chen, M
May, B
Zhou, I
Sze, M
Xue, C
Zhang, A
Year 2016
Journal name Critical Reviews in Oncology/Hematology
Volume number 105
Start page 18
End page 34
Total pages 17
Publisher Elsevier Ireland
Abstract This review assessed the effects on chemotherapy induced neutropenia (CIN) of combining oxaliplatin regimens with traditional plant-based medicines (TMs) in the management of colorectal cancer (CRC). 32 RCTs (2224 participants) were included. Meta-analysis showed reduced incidence of grade 3/4 CIN (RR 0.45[0.31, 0.65], I-2 = 0%). No studies reported serious adverse events or reduction in tumour response rates associated with concurrent use of oxaliplatin and TM. Due to small sample sizes and risk of bias, these results should be interpreted with caution. Analyses of sub-groups of studies that used similar TM interventions assessed the relative contributions of individual plant-based ingredients to the results. Astragalus, Codonopsis, Atractylodes, Poria and Coix, in various combinations were consistently associated with reduced CIN incidence when administered orally. Experimental studies of these plants have reported reduced myelosuppression and/or enhanced immune response. Further studies of these plants may lead to the development of interventions to supplement conventional CIN treatment.
Subject Traditional Chinese Medicine and Treatments
DOI - identifier 10.1016/j.critrevonc.2016.07.002
Copyright notice © 2016 Elsevier Ireland Ltd.
ISSN 1040-8428
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