Evaluation of the use of therapeutic peptides for cancer treatment

Marqus, S, Pirogova, E and Piva, T 2017, 'Evaluation of the use of therapeutic peptides for cancer treatment', Journal of Biomedical Science, vol. 24, no. 1, 21, pp. 1-15.


Document type: Journal Article
Collection: Journal Articles

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Title Evaluation of the use of therapeutic peptides for cancer treatment
Author(s) Marqus, S
Pirogova, E
Piva, T
Year 2017
Journal name Journal of Biomedical Science
Volume number 24
Issue number 1
Article Number 21
Start page 1
End page 15
Total pages 15
Publisher BioMed Central
Abstract Cancer along with cardiovascular disease are the main causes of death in the industrialised countries around the World. Conventional cancer treatments are losing their therapeutic uses due to drug resistance, lack of tumour selectivity and solubility and as such there is a need to develop new therapeutic agents. Therapeutic peptides are a promising and a novel approach to treat many diseases including cancer. They have several advantages over proteins or antibodies: as they are (a) easy to synthesise, (b) have a high target specificity and selectivity and (c)have low toxicity. Therapeutic peptides do have some significant drawbacks related to their stability and short half-life. In this review, strategies used to overcome peptide limitations and to enhance their therapeutic effect will be compared. The use of short cell permeable peptides that interfere and inhibit protein-protein interactions will also be evaluated.
Subject Cancer Cell Biology
Keyword(s) Cancer
Therapeutic peptides
Cell penetrating peptides
Apoptosis
DOI - identifier 10.1186/s12929-017-0328-x
Copyright notice © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution
ISSN 1021-7770
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