Theta-frequency phase-locking of single anterior cingulate cortex neurons and synchronization with the medial thalamus are modulated by visceral noxious stimulation in rats

Wang, J, Cao, B, Yu, T, Jelfs, B, Yan, J, Chan, R and Li, Y 2015, 'Theta-frequency phase-locking of single anterior cingulate cortex neurons and synchronization with the medial thalamus are modulated by visceral noxious stimulation in rats', Neuroscience, vol. 200, pp. 200-210.


Document type: Journal Article
Collection: Journal Articles

Title Theta-frequency phase-locking of single anterior cingulate cortex neurons and synchronization with the medial thalamus are modulated by visceral noxious stimulation in rats
Author(s) Wang, J
Cao, B
Yu, T
Jelfs, B
Yan, J
Chan, R
Li, Y
Year 2015
Journal name Neuroscience
Volume number 200
Start page 200
End page 210
Total pages 11
Publisher Elsevier
Abstract The rodent anterior cingulate cortex (ACC) is critical for visceral pain and pain-related aversive response in chronic visceral hypersensitive (VH) state. Long-term potentiation (LTP), induced by theta burst stimulation (TBS) in the medial thalamus (MT)-ACC pathway, is blocked in VH rats. However, the neuronal intrinsic firing characteristics and the MT-ACC connectivity have not been investigated in visceral pain. Using repetitive distension of the colon and rectum (rCRD) as a sensitization paradigm, we have identified that the spontaneous firing rates of ACC neurons and the CRD-stimulated neuronal firings were increased after repetitive visceral noxious stimulation. This correlates with increases in visceral pain responses (visceromotor responses, VMRs). Two multichannel arrays of electrodes were implanted in the MT and ACC. Recordings were performed in free-moving rats before and after repeated CRD treatment. Power spectral density analysis showed that the local field potential (LFP) recorded in the ACC displayed increases in theta band power (4-10 Hz) that were modulated by rCRD. Neural spike activity in the ACC becomes synchronized with ongoing theta oscillations of LFP. Furthermore, cross correlation analysis showed augmented synchronization of thalamo-ACC theta band LFPs, which was consistent with an increase of neuronal communication between the two regions. In conclusion, these results reveal theta oscillations and theta-frequency phase-locking as prominent features of neural activity in the ACC and a candidate neural mechanism underlying acute visceral pain.
Subject Neurosciences not elsewhere classified
Signal Processing
Keyword(s) anterior cingulate cortex
phase-locking
thalamocortical synchronization
theta oscillation
visceral pain
DOI - identifier 10.1016/j.neuroscience.2015.04.024
Copyright notice © 2015 The Authors.CC BY-NC-ND license
ISSN 0306-4522
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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