Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones

Zhai, X, Li, C, Lenon, G, Xue, C and Li, W 2017, 'Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones', Asian Journal of Pharmaceutical Sciences, vol. 12, no. 1, pp. 85-97.


Document type: Journal Article
Collection: Journal Articles

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Title Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones
Author(s) Zhai, X
Li, C
Lenon, G
Xue, C
Li, W
Year 2017
Journal name Asian Journal of Pharmaceutical Sciences
Volume number 12
Issue number 1
Start page 85
End page 97
Total pages 13
Publisher Elsevier BV
Abstract Total tanshinones are lipophilic active constituents extracted from Salvia miltiorrhiza Bge. Tanshinone IIA and cryptotanshinone are the major components in total tanshinones. However, the bioavailability of both compounds is low due to poor water solubility. To enhance the solubility and dissolution rate of tanshinone IIA, cryptotanshinone and total tanshinones, three common used hydrophilic carriers including PEG 6000, poloxamer 188 and PVP K30 were used to prepare the solid dispersions at different ratios, respectively. The solid dispersions were characterised by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The results of powder X-ray diffraction confirmed the microcrystal state of total tanshinones in solid dispersions and no chemical interaction between total tanshinones and carriers was observed in FTIR spectra. The solubility and dissolution rate of tanshinone IIA and cryptotanshinone were significantly increased in all solid dispersions. Regarding tanshinone IIA, the solubility and dissolution rate of in solid dispersions prepared with poloxamer 188 were significantly higher than that with PEG 6000 and PVP K30. The higher solubility and dissolution rate of cryptotanshinone were obtained in solid dispersion of PVP K30 than that of PEG 6000 solid dispersions but no significant difference from poloxamer 188 solid dispersions. The results indicate that the superior carrier for preparation of tanshinone IIA and total tanshinones solid dispersions is poloxamer 188, and that for cryptotanshinone is PVP K30.
Subject Traditional Chinese Medicine and Treatments
Metabolic Medicine
Keyword(s) Cryptotanshinone
Dissolution rate
Solid dispersion
Tanshinone IIA
Total tanshinones
DOI - identifier 10.1016/j.ajps.2016.08.004
Copyright notice © 2017 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license: http://creativecommons.org/licenses/by-nc-nd/4.0/
ISSN 1818-0876
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