Macrolactam analogues of macrolide natural products

Hugel, H, Smith, A and Rizzacasa, M 2016, 'Macrolactam analogues of macrolide natural products', Organic and Biomolecular Chemistry, vol. 14, no. 48, pp. 11301-11316.


Document type: Journal Article
Collection: Journal Articles

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Title Macrolactam analogues of macrolide natural products
Author(s) Hugel, H
Smith, A
Rizzacasa, M
Year 2016
Journal name Organic and Biomolecular Chemistry
Volume number 14
Issue number 48
Start page 11301
End page 11316
Total pages 16
Publisher Royal Society of Chemistry
Abstract The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity. The methods for the synthesis of several lactam analogues of macrolide natural products are highlighted and aspects of their biological properties presented.
Subject Natural Products Chemistry
Organic Chemical Synthesis
Medicinal and Biomolecular Chemistry not elsewhere classified
Keyword(s) macrolactams
aza-epothilone B
15-aza-salicylihalamide A
migrastatin lactam
radicicol macrolactams
DOI - identifier 10.1039/c6ob02149b
Copyright notice This journal is © The Royal Society of Chemistry 2016
ISSN 1477-0520
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