Identification of drugs that interact with herbs in drug development

Zhou, S, Zhou, Z, Chen, X, Li, C, Xue, C and Herington, A 2007, 'Identification of drugs that interact with herbs in drug development', Drug Discovery Today, vol. 12, no. 15-16, pp. 664-673.

Document type: Journal Article
Collection: Journal Articles

Title Identification of drugs that interact with herbs in drug development
Author(s) Zhou, S
Zhou, Z
Chen, X
Li, C
Xue, C
Herington, A
Year 2007
Journal name Drug Discovery Today
Volume number 12
Issue number 15-16
Start page 664
End page 673
Total pages 9
Publisher Elsevier Ltd., Trends Journals
Abstract To date, several clinically important drugs have been identified that interact with commonly used herbs. These drugs include (among others) warfarin, midazolam, digoxin, amitriptyline, indinavir, cyclosporine, tacrolimus and irinotecan. Importantly, many of these drugs have very narrow therapeutic indices. Most of them are substrates for cytochrome P450s (CYPs) and/or P-glycoprotein (P-gp). Because drug-herb interactions can significantly affect circulating levels of drug and, hence, alter the clinical outcome, the identification of drugs that interact with commonly used herbal medicines has important implications in drug development. In silico, in vitro, animal and human studies are often used to identify drug interactions with herbs. We propose that drug-herb and herb-CYP interaction studies should be incorporated into drug development. Because of the clinical significance of drug interactions with herbs, there is a strong necessity to identify drugs that may interact with herbal medicines in drug development.
Subject Complementary and Alternative Medicine not elsewhere classified
Keyword(s) drug-herb interactions
herb-CYP interactions
drug development
DOI - identifier 10.1016/j.drudis.2007.06.004
Copyright notice © 2007 Elsevier Ltd All rights reserved.
ISSN 1359-6446
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