The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature

Jamshidi, N and Cohen, M 2017, 'The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature', Evidence-based Complementary and Alternative Medicine, vol. 2017, 9217567, pp. 1-13.


Document type: Journal Article
Collection: Journal Articles

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Title The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature
Author(s) Jamshidi, N
Cohen, M
Year 2017
Journal name Evidence-based Complementary and Alternative Medicine
Volume number 2017
Article Number 9217567
Start page 1
End page 13
Total pages 13
Publisher Hindawi
Abstract Tulsi, also known as holy basil, is indigenous to the Indian continent and highly revered for its medicinal uses within the Ayurvedic and Siddha medical systems. Many in vitro, animal and human studies attest to tulsi having multiple therapeutic actions including adaptogenic, antimicrobial, anti-inflammatory, cardioprotective, and immunomodulatory effects, yet to date there are no systematic reviews of human research on tulsi's clinical efficacy and safety. We conducted a comprehensive literature review of human studies that reported on a clinical outcome after ingestion of tulsi. We searched for studies published in books, theses, conference proceedings, and electronic databases including Cochrane Library, Google Scholar, Embase, Medline, PubMed, Science Direct, and Indian Medical databases. A total of 24 studies were identified that reported therapeutic effects on metabolic disorders, cardiovascular disease, immunity, and neurocognition. All studies reported favourable clinical outcomes with no studies reporting any significant adverse events. The reviewed studies reinforce traditional uses and suggest tulsi is an effective treatment for lifestyle-related chronic diseases including diabetes, metabolic syndrome, and psychological stress. Further studies are required to explore mechanisms of action, clarify the dosage and dose form, and determine the populations mo st likely to benefit from tulsi's therapeutic effects.
Subject Complementary and Alternative Medicine not elsewhere classified
DOI - identifier 10.1155/2017/9217567
Copyright notice © 2017 Negar Jamshidi and Marc M. Cohen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ISSN 1741-427X
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