Distinguishing different stages of Parkinson's disease using composite index of speed and pen-pressure of sketching a spiral

Zham, P, Kumar, D, Dabnichki, P, Poosapadi Arjunan, S and Raghav, S 2017, 'Distinguishing different stages of Parkinson's disease using composite index of speed and pen-pressure of sketching a spiral', Frontiers in Neurology, vol. 8, 435, pp. 1-7.


Document type: Journal Article
Collection: Journal Articles

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Title Distinguishing different stages of Parkinson's disease using composite index of speed and pen-pressure of sketching a spiral
Author(s) Zham, P
Kumar, D
Dabnichki, P
Poosapadi Arjunan, S
Raghav, S
Year 2017
Journal name Frontiers in Neurology
Volume number 8
Article Number 435
Start page 1
End page 7
Total pages 7
Publisher Frontiers Research Foundation
Abstract The speed and pen-pressure while sketching a spiral are lower among Parkinson's disease (PD) patients with higher severity of the disease. However, the correlation between these features and the severity level (SL) of PD has been reported to be 0.4. There is a need for identifying parameters with a stronger correlation for considering this for accurate diagnosis of the disease. This study has proposed the use of the Composite Index of Speed and Pen-pressure (CISP) of sketching as a feature for analyzing the severity of PD. A total of 28 control group (CG) and 27 PD patients (total 55 participants) were recruited and assessed for Unified Parkinson's Disease Rating Scale (UPDRS). They drew guided Archimedean spiral on an A3 sheet. Speed, pen-pressure, and CISP were computed and analyzed to obtain their correlation with severity of the disease. The correlation of speed, pen-pressure, and CISP with the severity of PD was -0.415, -0.584, and -0.641, respectively. Mann-Whitney U test confirmed that CISP was suitable to distinguish between PD and CG, while non-parametric k-sample Kruskal-Wallis test confirmed that it was significantly different for PD SL-1 and PD SL-3. This shows that CISP during spiral sketching may be used to differentiate between CG and PD and between PD SL-1 and PD SL-3 but not SL-2.
Subject Biomedical Instrumentation
Biomedical Engineering not elsewhere classified
Keyword(s) Parkinson's
kinematic feature
speed
pen-pressure
dynamic handwriting features
DOI - identifier 10.3389/fneur.2017.00435
Copyright notice © 2017 Frontiers Media S.A. All Rights Reserved
ISSN 1664-2295
Additional Notes Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
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